Clinical Evaluation of an Immunological Method for Predicting the Efficacy of Assisted Reproductive Technologies

Introduction. Infertility in marriage is a relevant medical and social problem in many countries worldwide, for which assisted reproductive technologies are actively used. The effectiveness of infertility treatment depends on a number of factors. The study and correction of immune parameters in reproductive medicine may contribute to reducing the rate of population infertility. The aim of this study is to conduct a clinical trial of a method for the immunological prediction of the effectiveness of assisted reproductive technologies. Materials and methods. The method was trialed on 80 women with primary infertility, aged 19 to 47, prior to the use of assisted reproductive technologies. During the initial consultation, after obtaining informed consent, a blood sample was collected from the women, and serum was separated. The serum levels of Anti-Müllerian Hormone, Interleukin-18, and Sex Hormone-Binding Globulin were determined by enzyme-linked immunosorbent assay. Results. Analysis of changes in serum levels of the studied parameters revealed variations dependent on female fertility status. The detection model based on a combination of these parameters for predicting pregnancy onset demonstrated a sensitivity of 78.4% and a specificity of 62.1%. Discussion and сonclusion. Successful pilot testing of a method for the immunological prediction of the efficacy of assisted reproductive technologies in a cohort of women with primary infertility indicates its potential for use in immunodiagnostics, personalized assessment of pregnancy chances, and evaluation of the advisability of in vitro fertilization.