Clinical, social and psychological factors of the effectiveness of remission in alcohol dependence

Background. Alcohol dependence is one of the most socially significant diseases and is a multi-aspect problem in its mani-festations and consequences. The success of intervention in conditions of complicated clinical pictures and the course of alco-holism is associated with personalization of therapy, which allows for complete reduction of manifestations of withdrawal, comorbid emotional disorders and craving. In this regard, an urgent task is to study the factors influencing the effectiveness of remission formation. Objective: to study clinical, social, psychological factors influencing the effectiveness of remission for-mation in patients with alcohol dependence. Materials. The study included male patients (n=59) with the diagnosis of: Mental and behavioral disorders due to psychoactive substance use (ICD-10 codes F10-F19), aged 32 to 67 years (mean age 48 [43; 55] years). The examination was conducted at two control points ‒ after the patient came out of the abstinence state and at the time of discharge from the hospital. Methods: clinical-psychopathological, clinical-dynamic, psychometric, experimental-psychological, sociodemographic, statistical. Using a comparative analysis of the obtained data, potential factors of the inter-vention effectiveness were studied. Results: the risk group for unstable formation of remission in alcohol dependence included patients with an exacerbation of characterological traits of rigidity, conflict, with a reduced ability to rationally assess stressful situations (including those provoking the use of alcohol), prone to a pessimistic prognosis, with low compliance and impaired family adaptation. Clinical manifestations in these patients were characterized by a greater severity of the post-withdrawal state, difficulties in forming attitudes towards sobriety during treatment, psychopathic disorders in the form of aggressiveness, anger, deceit, manifestations of hysterical depression, overestimation of their importance, lack of empathy. The identified fea-tures should be taken into account at the stage of planning personalized therapy and during its implementation.