Клиническо-генетические особенности суицидального поведения больных, зависимых от синтетических катинонов

Клиническо-генетические особенности суицидального поведения больных, зависимых от синтетических катинонов

Автор: Асадуллин А.Р., Ахметова Э.А., Насифуллин А.И., Бадретдинов У.Г., Урицкий Б.Л.

Журнал: Суицидология @suicidology

Статья в выпуске: 4 (33) т.9, 2018 года.

Бесплатный доступ

В статье представлены данные обзора литературы и материал собственных исследований авторов, раскрывающий феномен суицидального поведения у зависимых от синтетических катинонов (СК) - нового поколения «дизайнерских» синтетических наркотических средств. Описаны основные сходства и различия патогенетических нейробиологических механизмов формирования аддиктивного и суицидального поведения. Цель статьи: анализ ассоциации суицидального поведения и тревоги, и выявление их распространённости среди зависимых от синтетических катинонов. Материал и методы: Обследовано 349 человек, в том числе 182 мужчины (23,7±0,8 лет) с сформированной зависимостью от стимуляторов (F15.2) и 167 здоровых лиц (22,8±0,6 года). Клинико-психопатологическим методом оценивалось суицидальное поведение, тревога в различные стадии интоксикации синтетическими катионами. Дополнительно проводилось генетическое исследование. Была выделена ДНК (фенолхлороформный метод) и проведён анализ распределения частот генотипов и аллелей полиморфных локусов rs6313 гена HTR2A и rs6296 гена HTR1B, определена ассоциация результатов генотипирования с отдельными формами суицидально поведения...

Еще

Синтетические катиноны, тревога, суицидальное поведение, наркомания, серотонинер-гическия система

Короткий адрес: https://sciup.org/140237154

IDR: 140237154   |   DOI: 10.32878/suiciderus.l8-09-04(33)-6l-73

Список литературы Клиническо-генетические особенности суицидального поведения больных, зависимых от синтетических катинонов

  • Turecki G., Brent D. A. Suicide and suicidal behavior. The Lancet. 2016; 387 (10024): 1227-1239.
  • Shahin M., Fouad A.A., Saleh A.A., Magdy A. Suicide risk and personality traits among Egyptian patients with substance use disorders. Egyptian Journal of Psychiatry. 2018; 39 (l): 15.
  • Михайловская Н.В. Некоторые социально-психологические характеристики больных наркоманиями, проявляющих суицидальную активность. Академический журнал Западной Сибири. 2013; 9 (5): 52-53.
  • McGirr A., Renaud J., Bureau A., Seguin M., Lesage A., Turecki G. Impulsive-aggressive behaviours and completed suicide across the life cycle: a predisposition for younger age of suicide. Psychological medicine. 2008; 38 (3): 407-417.
  • Chang H.B., Munroe S., Gray K., Porta G., Douaihy A., Marsland A., Brent D., Melhem N.M. The role of substance use, smoking, and inflammation in risk for suicidal behavior. Journal of affective disorders. 2019; 243: 33-41.
  • Darvishi N., Farhadi M., Haghtalab T., Poorolajal J. Alcohol-related risk of suicidal ideation, suicide attempt, and completed suicide: a meta-analysis. PloS one. 2015; 10 (5): 26-45.
  • Capron D.W., Bujarski S.J., Gratz K.L., Anestis M.D., Fairholme C.P., Tull M.T. Suicide risk among male substance users in residential treatment: Evaluation of the depression-distress amplification model. Psychiatry research. 2016; 237: 22-26.
  • Maloney E. et al. Impulsivity and borderline personality as risk factors for suicide attempts among opioid-dependent individuals. Psychiatry research. 2009; 169 (l): 16-21.
  • Matthieu M., Hensley M. Gatekeeper training outcomes: enhancing the capacity of staff in substance abuse treatment programs to prevent suicide in a high risk population. Mental Health and Substance Use. 2013; 6 (4): 274-286.
  • Асадуллин А.Р., Ахметова Э.А., Асадуллина Г.М., Шарипов А.Р., Тимербулатова М.Ф. Суициды и синтетические катиноны. Клинико-генетический анализ. Тюменский медицинский журнал. 2017; 19 (2): 12-15.
  • O’Neil K.A., Puleo C.M., Benjamin C.L., Podell J.L., Kendall P.C Suicidal ideation in anxiety-disordered youth. Suicide and Life-Threatening Behavior. 2012; 3: 305-317.
  • Foley D.L., Goldston D.B., Costello E.J., Angold A. Proximal psychiatric risk factors for suicidality in youth: the Great Smoky Mountains Study. Archives of general psychiatry. 2006; 9: 10171024.
  • Karch S.B., Drummer O. Karch's pathology of drug abuse. CRC. Press is an imprint of Taylor & Francis Group, an Informabusinepress; 2008; Dec: 15.
  • Arunotayanun W., Dalley J.W., Huang X.P., Setola V., Treble R., Iversen L., Roth B.L., Gibbons S. An analysis of the synthetic tryptamines AMT and 5-MeO-DALT: emerging ‘novel psychoactive drugs. Bioorganic & medical chemistry letters. 2013; 23: 3411-3415.
  • Асадуллин А.Р. Динамика потребления психоактивных веществ в Республике Башкортостан с углубленным клинико-генетическим изучением формирования зависимости от веществ группы синтетических катинонов: Автореф. дис.. д-рa. мед.наук. СПб, 2018. 34 с.
  • Valente M.J., De Pinho P.G., de Lourdes Bastos M., Carvalho F., Carvalho M. Khat and synthetic cathinones: a review. Archives of toxicology. 2014; 88 (1): 15-45.
  • Craufurd C. Yemen and Assir: El Dorado? Journal of the Royal Central Asian Society. 1933; 20 (4): 568-577.
  • Koppe H., Ludwig G., Zeile K. 1-(3', 4'-methylenedioxy-phenyl)-2-pyrrolidino-alkanones-(1): пат. 3478050 США, 1969.
  • Schoots O., Van Tol H.H.M. The human dopamine D4 receptor repeat sequences modulate expression. The Pharmacogenomics Journal. 2003; 3 (6): 343-348.
  • Падун М.А. Регуляция эмоций и ее нарушения. Психологические исследования: электронный научный журнал. 2015; 8 (39): 5-5.
  • Fadok J.P., Markovic M., Tovote P., Lüthi A. New perspectives on central amygdala function. Current opinion in neurobiology. 2018; 49: 141-147.
  • Civiero L., Greggio E. PAKs in the brain: function and dysfunction. Biochimica et Biophysica Acta (BBA). Molecular Basis of Disease. 2018; 1864 (2): 444-453.
  • Lucantonio F., Gardner M.P., Mirenzi A., Newman L.E., Takahashi Y.K., Schoenbaum G. Neural estimates of imagined outcomes in basolateral amygdala depend on orbitofrontal cortex. Journal of Neuroscience. 2015; 35 (50): 16521-16530.
  • Rubinow M.J., Mahajan G., May W., Overholser J.C., Jurjus G.J., Dieter L., Herbst N., Steffens D.C., Miguel-Hidalgo J.J., Rajkowska G., Stockmeier, C.A. Basolateral amygdala volume and cell numbers in major depressive disorder: a postmortem stereological study. Brain Structure and Function. 2016; 221 (1): 171-184.
  • McEwen B.S., Nasca C., Gray J.D. Stress effects on neuronal structure: hippocampus, amygdala, and prefrontal cortex. Neuropsychopharmacology. 2016; 41 (1): 3.
  • Grafman J., Schwab K., Warden D., Pridgen A., Brown H.R., Salazar A.M. Frontal lobe injuries, violence, and aggression: a report of the Vietnam Head Injury Study. Neurology. 1996; 46 (5): 1231-1251.
  • Kois L.E., Blakey S.M., Gardner B.O., McNally M.R., Johnson J.L., Hamer R.M., Elbogen E.B. Neuropsychological correlates of self-reported impulsivity and informant-reported maladaptive behaviour among veterans with posttraumatic stress disorder and traumatic Brain injury history. Brain injury. 2018; 32 (12): 14841491.
  • Baba T., Hosokai Y., Nishio Y., Kikuchi A., Hirayama K., Suzuki K., Hasegawa T., Aoki M., Takeda A., Mori,E. Longitudinal study of cognitive and cerebral metabolic changes in Parkinson's disease. Journal of the neurological sciences. 2017; 372: 288293.
  • Koob G.F., Nestler E.J. The neurobiology of drug addiction. The Journal of neuropsychiatry and clinical neurosciences. 1997; 4: 76-79.
  • Marusich J.A., Gay E.A., Blough B.E. Analysis of neurotransmitter levels in addiction-related brain regions during synthetic cathinone self-administration in male Sprague-Dawleyrats. Psychopharmacology. 2018; 6: 1-12.
  • Mueller C.P., Homberg J.R. The role of serotonin in drug use and addiction. Behavioural brain research. 2015; 277: 146-192.
  • Brodie B.B., Shore P.A. A concept for a role of serotonin and norepinephrine as chemical mediators in the brain. Annals of the New York Academy of Sciences. 1957; 66 (3): 631-642.
  • Brown G.L. et al. Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry research. 1979; 1 (2): 131-139.
  • Bani-Fatemi A., Jeremian R., Wang K.Z., Silveira J., Zai C., Kolla N.J., De Luca V. Epigenome-wide association study of suicide attempt in schizophrenia. Journal of Psychiatric Research. active drugs. Bioorganic & medical chemistry letters. 2013; 23: 3411-3415.
  • Simmler L.D., Rickli A., Hoener M.C., Liechti M.E. Monoamine transporter and receptor interaction profiles of a new series of designer cathinones. Neuropharmacology. 2014; 79: 152-160.
  • Zhukovsky P., Alsiö J., Jupp B., Xia J., Guiliano C., Jenner L., Griffiths J., Riley E., Ali S., Roberts A.C., Robbins T.W. Perseveration in a spatial-discrimination serial reversal learning task is differentially affected by MAO-A and MAO-B inhibition and associated with reduced anxiety and peripheral serotonin levels. Psychopharmacology. 2017; 234 (9-10): 1557-1571.
  • Lammel S., Lim B.K., Malenka R.C. Reward and aversion in a heterogeneous midbrain dopamine system. Neuropharmacology. 2014; 76: 351-359.
  • Croft R.J., Klugman A., Baldeweg T., Gruzelier J.H. Electrophysiological Evidence of Serotonergic Impairment in Long-Term MDMA ("Ecstasy") Users. American Journal of Psychiatry. 2001; 158 (10): 1687-1692.
  • Manchia M., Carpiniello B., Valtorta F., Comai S. Serotonin dysfunction, aggressive behavior, and mental illness: exploring the link using a dimensional approach. ACS chemical neuroscience. 2017; 8 (5): 961-972.
  • Brosda J., Müller N., Bert B., Fink H. Modulatory Role of Postsynaptic 5-Hydroxytryptamine Type 1A Receptors in (±)-8-Hydroxy-N, N-dipropyl-2-aminotetralin-Induced Hyperphagia in Mice. ACS chemical neuroscience. 2015; 6 (7): 1176-1185.
  • Banlaki Z., Elek Z., Nanasi T., Szekely A., Nemoda Z., Sasvari-Szekely M., Ronai, Z. Polymorphism in the serotonin receptor 2a (HTR2A) gene as possible predisposal factor for aggressive traits. PLoS one. 2015; 10 (2): e0117792.
  • Nautiyal K.M. et al. Distinct circuits underlie the effects of 5-HT1B receptors on aggression and impulsivity. Neuron. 2015; 86 (3): 813-826.
  • Hervig M.E.S., Jensen N.C.H., Rasmussen N.B., Rydbirk R., Olesen M.V., Hay-Schmidt A., Pakkenberg B., Aznar S. Involvement of serotonin 2A receptor activation in modulating medial prefrontal cortex and amygdala neuronal activation during novelty-exposure. Behavioural brain research. 2017; 326: 1-12.
  • Murphy T.M., Ryan M., Foster T., Kelly C., McClelland R., O'Grady J., Corcoran E., Brady J., Reilly M., Jeffers A., Brown K. Risk and protective genetic variants in suicidal behaviour: association with SLC1A2, SLC1A3, 5-HTR1B & NTRK2 polymorphisms. Behavioral and Brain Functions. 2011; 7 (1): 22.
  • Antypa N., Serretti A., Rujescu D. Serotonergic genes and suicide: a systematic review. European Neuropsychopharmacology. 2013; 23:1125-1142.
  • Wrzosek M., Lukaszkiewicz J., Wrzosek M., Serafin P., Jakubczyk A., Klimkiewicz A., Matsumoto H., Brower K.J., Wojnar M. Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report. Psychiatryresearch. 2011; 190: 149-151.
  • Зотов П.Б. Вопросы идентификации клинических форм и классификации суицидального поведения. Академический журнал Западной Сибири. 2010; 3: 35-37.
  • Kessler R.C., Berglund P., Demler O., Jin R., Merikangas K.R., Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Archives of general psychiatry. 2005; 62 (6): 593-602.
  • Daniel J.J., Hughes, R.N. Increased anxiety and impaired spatial memory in young adult rats following adolescent exposure to methylone. Pharmacology Biochemistry and Behavior. 2016; 146: 44-49.
  • Cao J., Hudziak J.J., Li D. Multi-cultural association of the serotonin transporter gene (SLC6A4) with substance use disorder. Neuropsychopharmacology. 2013; 38 (9): 1737.
  • White V.M., Hopper J.L., Wearing A.J., Hill D.J. The role of genes in tobacco smoking during adolescence and young adulthood: a multivariate behaviour genetic investigation. Addiction. 2003; 98 (8): 1087-1100.
  • Goldstein R.Z., Volkow N.D. Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex. American Journal of Psychiatry. 2002; 159 (10): 1642-1652.
  • Kao W.T., Yang M.C., Lung F.W. Association between HTR1B 104: 192-197.
  • Herman A.I., Balogh K.N. Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. Substance abuse and rehabilitation. 2012; 3: 49.
  • Gizer I.R., Ficks C., Waldman I.D. Candidate gene studies of ADHD: a meta-analytic review. Human genetics. 2009; 126 (l): 51-90.
  • Ghasemi A., Seifi M., Baybordi F., Danaei N., Rad, B.S. Association between serotonin 2A receptor genetic variations, stressful life events and suicide. Gene. 2018; 658: 191-197. alleles and suicidal ideation in individuals with major depressive disorder. Neuroscience letters. 2017; 638: 204-210.
  • Herman A.I., Balogh K.N. Polymorphisms of the serotonin transporter and receptor genes: susceptibility to substance abuse. Substance abuse and rehabilitation. 2012; 3: 49.
  • Gizer I.R., Ficks C., Waldman I.D. Candidate gene studies of ADHD: a meta-analytic review. Human genetics. 2009; 126 (l): 51-90.
  • Ghasemi A., Seifi M., Baybordi F., Danaei N., Rad, B.S. Association between serotonin 2A receptor Genetic variations, stressful life events and suicide. Gene. 2018; 658: 191-197.
Еще
Статья научная
QR-код для установки приложения SciUp Наведите камеру и скачайте бесплатное приложение SciUp