Clinical and hematological peculiarities for hormonal drug administration after pharmacological termination of early non-developing pregnancy

One of the major challenges in modern gynecology is the problem of non-developing pregnancy. In particular, it is not still clear whether patients should be administered certain hormonal drugs and when such drugs should be taken. The purpose of the study was to assess endometrium and hemostatic system in women taking hormonal drugs after pharmacological termination of a non-developing pregnancy. Materials and Methods. The authors examined 60 women who underwent medical termination of a nondeveloping pregnancy. During the post-abortion period, one group of women took a hormonal drug containing 30 μg of ethinylestradiol and 0.15 mg of desogestrel, and another group took a hormonal drug containing 20 mg of dydrogesterone. The authors evaluated hemostasis indicators and data of a sonographic endometrium study and compared the results obtained with parameters observed in women who did not take any hormonal drugs. Results. Improvement of hemostatic system parameters was observed without hormonal rehabilitation in the post-abortion period. Nonetheless, in 75 % of cases there was a discrepancy between ultrasound indicants and a phase of the menstrual cycle. Moreover, focal and diffuse endometrial hyperplasia was formed in 58 % of cases. Menstrual cycle normalization and lack of excessive endometrium proliferation were observed under hormonal therapy. However, at the same time agitation of the hemostatic system was noted. Thus, platelet aggregation time reduced by 20.2 % (from 17.3±3.1 to 13.8±1.8 s, p function show_eabstract() { $('#eabstract1').hide(); $('#eabstract2').show(); $('#eabstract_expand').hide(); }