Clinical and genetic characteristics of young and middle-aged patients with ischemic stroke

Analysis of genetic risk factors for acute cerebral ischemia was conducted to study the gene polymorphism of hemostasis system (as a predictor of ischemic stroke). Polymorphic variants of the genes of blood coagulation were studied in young and middle-aged patients with ischemic stroke (IS). Materials and Methods. 172 patients were enrolled in the trial. Genetic polymorphisms, which contributed to ischemic brain damage and were literature reported, were chosen for the study, namely: FII gene polymorphism 20210G>A, FV gene polymorphism 1691G>A, FVII gene polymorphisms 10976G>A, FGB gene polymorphism -455G>A, PAI-1 gene polymorphism -675 5G>4G, ITGA2 gene polymorphism 807C>T, and ITGB3 gene polymorphism 1565T>C. The authors used the technology of detecting and identifying single nucleotide polymorphisms (SNPs) using melting temperature curve analysis (“DNA-technology"). The influence of genetic factors on the acute phase as well as ischemic stroke (IS) outcome in the examined group of patients was studied. Results. In patience with IS polymorphic variants of FBG, FII, F5, ITGB3 genes predominated (as compared to a control group). The most frequent was 455G>A fibrinogen gene polymorphism. Polymorphic variants of blood coagulation genes determined clinical features of acute ischemic stroke (pathogenic stroke subtype, number of ischemic sites, severity of neurological deficit). Moreover, they did not affect the functional outcome by the end of the acute phase of the disease. It was found that genetic predisposition to thrombophilic states played an essential role in the development of ischemic stroke in young and middle-aged people.