Clinical-immunologic characteristics of mixed herpes viral infections in babies

Aimed at optimization of herpes viral infections diagnosis, 186 babies who had momo- or mixed herpes viral infections were examined. Their blood, liquor, urine, saliva and materials that were scrapped off in the damaged focus (skin, mucous membrane of the mouth) were studied by methods of IFA, RIF, PCR. Сlinical and immunologic parallels were studied. Levels of TNF-а, IL-4 and IFN-а in blood serum and in liquor were assessed. Generalized form of mixed infection was characterized by low contents of TNF-а, IL-4 and IFN-а in blood serum and higher level of TNF-а in the liquor which in the setting of increased antigen load pointed to the disruption of mechanisms of adaptation and compensation and bad prognosis.