Clinical and laboratory characteristics of children with Marshall syndrome

Clinical and laboratory characteristics of children observed in the Children''s Republican Clinical Hospital with the diagnosis of Marshall Syndrome (PFAPA) are presented in the article. 8 children have been monitored from 2009 to 2017. The average age of patients was 5.4 ± 1.2 years, the ratio of girls: boys 3: 5, of which the Buryats - 7, the Caucasians - 1. A general blood test, biochemical blood test, immunological methods - immunogram, antinuclear factor (ANF), pharyngoscopy have been used in the diagnosis. According to the authors, in all children the main diagnostic symptom that allowed to suspect PFAPA syndrome was fever, the second diagnostic criterion in absolute representation was pharyngitis, which was characterized as catarrhal and accompanied by a bloom on the palatine tonsils. The course of the onset of the PFAPA syndrome was accompanied by moderate leukocytosis with neutrophilia, as well as an increase in the level of acute phase parameters. According to the results of the immunogram study, there were no signs of immunodeficiency in any patient. After the diagnosis was established, prednisolone has been used in all patients. Three children reached school age and underwent tonsillectomy, which also in 100% of cases allowed to stop the periods of prolonged febrility with the characteristic clinical symptoms of PFAPA syndrome.