Clinical and laboratory characteristics of patients with chronic kidney disease 5D depending on the episode of SARS-CoV-2 infection

Introduction. The prevalence of chronic kidney disease is steadily increasing. However, at the same time, even terminal renal failure is not a “verdict”, since there are well-proven methods of renal replacement therapy, the spectrum of which is quite wide. The COVID-19 pandemic has significantly reduced the cohort of dialysis patients. However, unfortunately, the very fact of the transferred disease has negative consequences in the long term. The purpose of this study was to search for predictors of an unfavorable outcome in patients with a confirmed diagnosis of COVID-19 receiving treatment with programmed hemodialysis. Patients and methods. 62 patients with chronic kidney disease of stage C5 receiving HD treatment were examined. The patients were divided into 2 groups: group 1 (41 people) - those who were diagnosed with COVID-19 and group 2 (21 people) - those who were not. To assess the condition, biochemical parameters of the protocol for the management of dialysis patients, food diaries, and caliperometry were used. Results. The incidence was statistically significantly affected by visceral obesity, insufficient protein intake, excessive fat intake, impaired carbohydrate tolerance, hyperleptinemia and the presence of any cardiovascular disease. During the two-year follow-up, 15 people died. At the same time, there were 14 patients in the group of COVID-19 patients. Accordingly, mortality in the group of patients without a history of COVID-19 amounted to 4.7%, in the comparison group - 35%. Conclusion. The most likely cause of high mortality in patients who have undergone COVID-19 is protein-energy deficiency. In obese patients, its development may not attract attention for a long time due to the fact that the BMI is in the formally safe range.