Clinical and pathogenetic aspects of ischaemic heart disease complicated by chtonic heart failure
Автор: Dorofeeva N.P., Pleskachev S.A., Shlyk S.V., Tchigaeva E.V., Therananyanz E.A., Mashtalova O.G., Koulikova I.E., Pleskachev A.S., Todorov S.S.
Журнал: Клиническая практика @clinpractice
Рубрика: Оригинальные исследования
Статья в выпуске: 1 (5), 2011 года.
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Objectives: To investigate genetic and neurohumoral determinants of chronic heart failure (CHF) development and progression in ischaemic heart disease (IHD) patients. Methods: Serum neurohormone level analysis (angiotensin II, aldosterone, endotheline1, NTproBNP, TNFα) and genotyping (genes encoding ACE, angiotensinogen, and type1 angiotensin II receptors ) were implemented in 100 patients Results: Activation of endotheline and NTproBNP is characteristic of early CHF stages while decompensation of chronic heart failure shows elevation in aldosterone and TNFα. Structural polymorphism of renineangiotensine system genes is not significant in CHF development and progression in IHD patients.
Neurohormones, genetic polymorphism, reninangeotensin system, chronic heart failure
Короткий адрес: https://sciup.org/14338366
IDR: 14338366
