Cognitive and electroencephalographic changes in patients undergoing a seizure, suffering from alcohol dependence

Introduction. Progressive impairment of intellectual functions is a characteristic feature of alcohol dependence. Cognitive disorders in persons suffering from chronic alcoholism are detected in 50-70% of cases, in 10% of cases they are pronounced, reaching the degree of dementia. Materials and methods. 149 patients with stage II-III alcohol dependence are examined. Cognitive impairment is assessed using a Short scale assessment of mental status (MMSE), EEG investigation is performed. Results. Electroencephalographic examination is characterized by absence of typical EPI phenomena. Also during EEG a decrease in the power of the main rhythm and an increase in the specific weight of slow wave activity of theta and Delta bands are revealed. A comparative analysis of cognitive impairment according to the MMSE scale as a result of treatment shows significant differences between groups. Conclusion. Appropriate therapy (vitamin therapy, nutrition normalization, use of drugs that stimulate neurotransmitter systems (peptides, cholinergic agents, neurometabolites, NMDA receptor blockers) leads to recovery of cognitive functions.