Comorbidity with upper gastrointestinal diseases at chronic inflammatory enteropathy

Polymorbidity requires enhanced diagnostic and treatment protocols for patients and affects the disease prognosis and outcome. Chronic inflammatory bowel diseases (CIBD), especially comorbid conditions including gastroesophageal reflux disease (GERD), gastroduodenitis and peptic ulcer disease are difficult to diagnose, as they are characterized by similar clinical manifestations, polysystemic lesions and sometimes even invasion of the upper gastrointestinal tract. Medical records of patients with polymorbidity were selected from records of all the patients treated in hospital division of gastroenterology over a three-year period, including those suffering from CIBD (ulcerative colitis and Crohn's disease) together with upper gastrointestinal diseases. Polymorbidity was diagnosed in 54,3 %. It was observed in 78,6 % in patients with CIBD. Its frequency was the same in ulcerative colitis and Crohn's disease. Age of polymorbid patients with CIBD was 39,5±1,7; the male to female ratio was 8:1, CCI - 2,17±0,29 (95 %, CI (1,53; 2,74)). The male to female ratio with co-morbid occurrence of ulcerative colitis and Crohn's disease was the same. Patients with Crohn's disease were younger, but they had a higher Charlson Comorbidity Index (CCI), which indicated a more severe course of their underlying and concomitant diseases. Comorbidity with gastroenterological pathology in patients with CIBD was diagnosed in 63,3 %; there was no considerable difference between patient with ulcerative colitis and Crohn's disease. Upper gastrointestinal diseases together with CIBD were detected in 46,9 %; again there was no significant difference between patient with ulcerative colitis and Crohn's disease. GERD was revealed in 6,1 %, and chronic gastritis - in 6,1 %. Comorbid conditions including duodenum were diagnosed more often (34,7 % of patients). No difference was found in comorbid upper gastrointestinal diseases in patients with ulcerative colitis and Crohn's disease. Thus, peculiarities of comorbidity with upper gastrointestinal diseases in patients with CIBD: duodenum was involved more often than esophagus and stomach; patients with ulcerative colitis were older than patients with Crohn's disease; patients with Crohn's disease had a more severe course of the underlying and concomitant pathology.