Conformational effects in allyl-substituted thioand oxyquinolines

The conformational analysis of allylthio- and allyloxyquinolines with substitution in 2 or 8 position was carried out. Conformational states with intramolecular hydrogen bond N.H-C prevent the formation of intermolecu-lar interactions upon the nitrogen atom in the quinoline. These conformations states promote to stabilization molecular geometry with closely spaced reaction centers in accordance with experimental data about iodocyclisation process.