The correction of endothelial dysfunction is a promising direction for the therapy of acute kidney injury

Introduction. Acute kidney injury (AKI), which is based on ischemic-reperfusion damage, is a widespread life-threatening condition and remains a serious public health problem with a high mortality rate among patients. Despite significant advances in various areas of medicine, the prevention and correction of ischemic-reperfusion kidney damage are still far from being at the desired level. Pharmacological preconditioning and the use of endothelio-protectors are promising areas in this field, therefore the purpose of this study was to analyze the nephroprotective properties of selective inhibitor of arginase II KUD975 in ischemic kidney damage in the experiment. Objective. To study the possibility of preventing ischemia-reperfusion kidney injury with the selective inhibitor of arginase II - KUD975. Materials and methods. In a series of experiments on Wistar male rats, the protective effects of the prophylactic use of an inhibitor of arginase II-KUD975 at doses of 1 mg / kg and 3 mg / kg were compared with the non-selective arginase inhibitor L-norva-line on a 40-minute bilateral model of renal ischemia-reperfusion...