Dislipudemia correction at advanced age patients with ecologically associated risk factors

At 117 patients of advanced age without clinical displays of ischemic heart diseases having under table SCORE very high 10-years risk of mortality from cardiovascular diseases (СVD) the efficiency aggres-sive lipid-correcting pharmacotherapy is estimated. It is established, that statin choice should be based on a complex estimation: their categories of risk; initial LDL-level, degree of its depression for achievement of target value and data of evidence based medicine by statins efficiency. To patients with high LDL-level it is recommended rosuvastatin in doze 10 mg/day, with moderately increased - atorvas-tatin in doze 20 mg/day and with optimum - simvastatin in doze 40 mg/day. After 3 months under statin influence the optimization of lipid parameters (total cholesterol, low-density lipoproteins, high-density lipoproteins, atherogenic index and triglycerides) is noted. Thus, despite of the unidirectional positive changes of these parameters under the influence of rosuvastatin, atorvastatin and simvastatin at their separate quantitative estimation essential differences are taped. If to accept depression of LDL-level on a background of reception rosuvastatin in doze of 10 mg/day for unit (1,0), atorvastatin in doze 20 mg/day made relative value - 0,65, simvastatin in doze 40 mg/day - only 0,43.