Correction of endothelial dysfunction in patients with terminal renal insufficiency

The problem of development of endothelial disfunction in patients with end-stage renal failure and possibilities of its correction in extracorporal and medical methods is discussed.In research took part 60 patients with chronic kidney disease stage V by K/DOQI, which was evaluated vasomotor endothelial function in samples with reactive hyperemia and nitroglycerin, with simultaneous detection of the concentration of endothelin-1. The study confirmed the expressed changes of indicators vasodilating activity of the vascular wall and raising of endothelin-1 level in patients of this group. Effective method of correction of endothelial disfunction in patients with terminal renal insufficiency was early initiation of haemodyalisis therapy in combination with ACE inhibitors pharmacotherapy.