Correction of aggressive behavior patterns by ex vivo modulated immunocompetent cells: an experimental study

Background. Aggression and aggressive behavior is a serious medical and biological problem, including thoseassociated with a high prevalence among psychiatric patients and the lack of selective corrective means. The study ofthe pathogenetic mechanisms of aggression and the search for approaches to therapy within the framework of neuro-immune interaction is currently an extremely promising direction. The significant role of immunocompetent cells andtheir biologically active products in the pathogenesis of aggression, the unidirectional effect of most psychoactivesubstances on the cells of the central nervous system and the immune system allow us to consider immunocompetentcells as model objects for influencing the intersystem functional relationship in order to correct aggressive behavior.Objective: to study the effect of immunocompetent cells modulated ex vivo by a psychoactive substance on the behavior patterns of aggressive animals. Materials and Methods. The study was performed on 4-month-old male mice(CBAxC57BL/6)F1. Results and Discussion. It has been shown that in vitro treatment of splenocytes of aggressivemice with aminazine changes the functional activity of cells, which is expressed in a decrease in proliferative activityand production of cytokines IL-2, IL-6, and IFN-y. Transplantation of immunocompetent cells of aggressive donorsmodulated ex vivo with aminazine achieves editing of aggressive behavior patterns in syngeneic aggressive recipients, as evidenced by a decrease in aggressive motivation, the level of aggressiveness, anxiety, and locomotor activity. The presented results show the promise of using cellular technologies to correct aggressive behavior.