Lipofiling and possibilities of its application for treatment of post-radium injuries of the rectal column

Objective. To analyze the possibilities of using lipofilling for the treatment of post-radiation damage to the rectum.Material and methods. The object of the study is female patients aged 28 to 83 years, inclusive, with complications of radiation therapy (rectovaginal fistulas, radiation proctitis, radiation ulcers). Methods used: analysis of literary sources, publications, review of used treatment methods, analysis of statistical data, analysis of history and results of treatment, generalization, systematization, classification of literature data.Results. Due to lipofilling, it is possible to normalize the structure of soft tissues, achieve healing of wound surfaces, eliminate scar deformities, and also by assessing the quality of life of patients. The healing process was assessed by clinical and histological methods. The clinical picture included a gradual decrease in the size of the fistula, a decrease in inflammation, and restoration of the vaginal and rectal mucosa.The residual hole closed spontaneously. The results also indicate a significant increase in the quality of life of patients after treatment. We have evaluated the effectiveness of the lipofilling method based on the introduction of mesenchymal stem cells of adipose tissue into damaged tissues. The healing process was assessed by clinical and histological methods. As a result of treatment, there is a tendency to improve the quality of life of patients. Improvement is noted for all the studied indicators. Conclusion. Our data indicate the effectiveness of the developed by us technique of microinjection autotransplantation of adipose tissues.