"Лёгкое-на-чипе" как инструмент для изучения патофизиологии дыхания человека

"Лёгкое-на-чипе" как инструмент для изучения патофизиологии дыхания человека

Автор: Жукова О.А., Озерская Ю.В., Басманов Д.В., Столяров В.Ю., Богуш В.Г., Колесов В.В., Зыков К.А., Юсубалиева Г.М., Баклаушев В.П.

Журнал: Клиническая практика @clinpractice

Рубрика: Научные обзоры

Статья в выпуске: 4 т.15, 2024 года.

Бесплатный доступ

«Лёгкое-на-чипе» (от англ. Lung-on-a-Chip, LoC) - микрофлюидное устройство, имитирующее газожидкостный интерфейс лёгочной альвеолы человека и предназначенное для патофизиологических, фармакологических и молекулярно-биологических исследований гематоальвеолярного барьера in vitro. Устройство LoC включает систему жидкостных и газовых микроканалов, разделённых полупроницаемой эластичной мембраной, содержащей полимерную основу и клеточные элементы альвеолы. В зависимости от вида LoC (одно-, двух- и трёхканальное) на мембране могут находиться только альвеолоциты или альвеолоциты в сочетании с другими клетками - эндотелиоцитами, фибробластами, альвеолярными макрофагами, опухолевыми клетками. Некоторые модели LoC также включают белковую или гидрогелевую строму, имитирующую лёгочный интерстиций. Первый двухканальный вариант LoC, в котором с одной стороны мембраны находится монослой альвеолоцитов, а с другой - монослой эндотелиоцитов, был разработан в 2010 году группой учёных Гарвардского университета с целью максимально точного воспроизведения in vitro микроокружения и биомеханики работы альвеолы. Современные модификации LoC включают те же элементы и отличаются лишь конструкцией микрофлюидной системы, биоматериалом полупроницаемой мембраны, составом клеточных и стромальных элементов и решаемыми специальными задачами. Помимо LoC, воспроизводящих гематоальвеолярный барьер, существуют модификации для исследования определённых патофизиологических процессов, скрининга лекарственных препаратов, моделирования конкретных заболеваний, например рака лёгкого, хронической обструктивной болезни лёгких или астмы. В данном обзоре мы проанализировали существующие разновидности LoC, применяемые биоматериалы, методы детекции молекулярных процессов в микрофлюидных устройствах и основные направления исследований с помощью «лёгкого-на-чипе».

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Лёгкое-на-чипе, гематоальвеолярный барьер, болезни органов дыхания, микрофлюидные устройства

Короткий адрес: https://sciup.org/143183766

IDR: 143183766   |   DOI: 10.17816/clinpract637140

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