Математическое моделирование и биомеханический подход к описанию развития, диагностики и лечения онкологических заболеваний
Автор: Кучумов А.Г.
Журнал: Российский журнал биомеханики @journal-biomech
Статья в выпуске: 4 (50) т.14, 2010 года.
Бесплатный доступ
Развитие раковых опухолей связано с различными химическими, генетическими, физиологическими и механическими факторами, которые происходят как на субклеточном и клеточном уровнях, так и на уровнях тканей и органов. В последние десятилетия наблюдается прогресс в выявлении и объяснении процессов, возникающих при развитии раковых заболеваний, а также разработке методов и средств для ранней диагностики и лечения болезни. Значительный вклад в решение данной проблемы, с одной стороны, привнесло развитие биотехнологий и медицины, с другой стороны, такие направления науки, как математическое моделирование и биомеханические исследования, позволяют смоделировать поведение клеток и органов до болезни, при её развитии и лечении, обходясь без сложнейших наблюдений in vivo. В данной работе приведен обзор явлений, которые возникают при зарождении и развитии болезни, описана роль математики и биомеханики в описании и объяснении данных процессов, а также лечении онкологических опухолей. Следует обратить особое внимание на внедрение новых мультимасштабных моделей, которые описывают состояние болезни как на микроуровне, так и на мезо- и макроуровнях.
Рак, клеточная механика, механотрансдукция, ангиогенез, мультимасштабный подход
Короткий адрес: https://sciup.org/146216007
IDR: 146216007
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