Mechanochemical production of a food supplement containing vitamin D and chelated forms of silicon

Systemic deficiency of vitamin D and silicon compounds in the human body leads to numerous negative consequences, primarily in the field of the functioning of the musculoskeletal system: even in the absence of a lack of calcium and phosphorus compounds, which are considered to be the main bone-forming substances, bone mineralization substances, the likelihood of falls and fractures increases, muscle pain occurs. Based on the known mechanisms of the physiological action of vitamin D and silicon on the human body, it was assumed in this work that a food supplement containing cholecalciferol and water-soluble chelated forms of silicon will have a synergistic effect. It was shown that using solid-phase mechanochemical treatment in the optimal mode, a product containing water-soluble chelated silicon compounds with an equilibrium concentration of up to 24 mg / l is obtained from rice husks and green tea. The optimal mode, characterized by high resistance to instabilities of the technological process, obtaining a product containing chelated silicon compounds from rice husk and green tea, is the rotor speed of the RM-50 semi-industrial centrifugal roller mill-activator equal to 1200 rpm at a feed rate of processing area equal to 43 kg / h. The resulting prototype was used as a solid matrix - the basis for applying cholecalciferol and obtaining a biologically active food supplement. The calculated amounts of the supplement required for consumption to replenish the body's daily need for vitamin D have shown the advisability of using soluble gelatin capsules.