Topically irritating and allergenic properties of tomato supernatants

Profilins contained in tomatoes are one of the most common allergens. These substances have been identified as pan-allergens that can cause allergic reactions in response to ingestion of various foods and plant pollen. Sensitization to profilin is observed in approximately 20% of patients with pollen allergy. IgE, which is specific to pollen profilins, causes a cross-reaction with fruit and vegetable profilins. In patients with tomato allergy and multiple sensitisation to other food sources and pollen, IgE is directed to Lyc e1. Lyc e1 has demonstrated allergenic activity due to its ability to induce the release of inflammatory mediators from human basophils in vitro. Therefore, it is likely that Lyc e1 contributes significantly to the development of clinical symptoms in patients with tomato allergy. As part of the study, the irritant and allergic effects of\supernatants were studied. Studies have shown that supernatants have a moderate irritating effect on the mucous membranes of the eyes during the first 2 days of treatment. Two highly sensitive tests for determining allergizing activity - "histamine shock" and mast cell degranulation reaction — showed that when parenterally administered, all samples do not potentiate the effect of histamine and do not cause mast cell degranulations of experimental animals that go beyond the established norms. The absence of a pronounced irritant effect and autoimmune activity in supernatants allows them to be used as a component of soft drinks, including for special purposes.