Metabolic adaptation of oxidoreductases of erythrocytes to glutathione-containing dinitrosyl iron complexes

The aim of this work is estimation of action of dinitrosyl iron complexes (DNIC) on rats blood energy metabolism at combined thermal trauma. We studied 30 Wistar rats, divided into 3 groups: intact (n=10), control (n=10) and main (n=10) group. We modeled combined thermal trauma (skin burn + thermoinhalation damage) in animals of control and main groups. Rats of control group got a infusions of sodium chloride solution (n=10) every day. Rats of main one got infusions of DNIC solution in sodium chloride. In blood samples we studied activity of lactate dehydrogenase in direct and reverse reaction, lactate level and coefficients of substrate provision and energy reactions balance. It was stated, that DNIC clearly normalized erythrocytes energy metabolism from third day after trauma.