Metabolic and coagulation activity of lungs in experimental ischemic and hemorrhagic stroke

In the present work the metabolic and coagulation activity of lung after experimental intraventricular hemorrhage and cerebral ischemia was explored. It is shown that the experimental hemorrhagic and ischemic stroke was accompanied by the changes of the phospholipids composition in arterial and venous blood, such as the decrease of phosphatidylcholine and increase of lysophosphatidylcholine. Besides, a decline of the uptake of phosphatidic acid by the lung was found out. Intracerebral hemorrhage and cerebral ischemia resulted in the disturbance of normally presented lung hypocoagulation capacity characterized by the decrease of procoagulant activity after the pass of pulmonary circulation.