Metabolic risk factors and urinary stones formation. Study V: overweight and obesity as metabolic factors of lithogenesis

Introduction. Abdominal obesity has been considered an important risk factor for the development of urolithiasis in recent years. In this paper, we investigated the influence of the degree of obesity in patients with urolithiasis on metabolic parameters and the frequency of detection of urinary stones of various chemical compositions. Materials and methods. the mineral composition of 701 urinary concretions (from 302 men and 399 women aged 16 to 81 years) was studied by infrared spectroscopy. The degree of obesity was assessed by the body mass index (BMI) according to WHO criteria. Results. In comparison between patients of normal body weight and patients with overweight (pre-obesity) and obesity patients showed a progressive increase in the frequency of uric acid stones as the severity of obesity increased. Thus, the frequency of uric acid stones increased from 6.4% (BMI 18.5-24.9 kg/m2) to 18.1% in overweight (BMI 25.0-29.9 kg/m2), to 31.3% in 1 obesity 1 degree (BMI 30.0-34.9 kg/m2), to 35.0% among patients with 2-3 degrees obesity (BMI 35.0-57.3 kg/m2, p2), exceeding this indicator by 4 times compared to women. Metaphylaxis of uric acid urolithiasis in men with various degrees of obesity should include, in addition to measures to normalize body weight, measures to eliminate the influence of metabolic lithogenic factors caused by obesity.