Metabolism of porphyrinic fractions of pregnant women with fetoplacental insuffiency with hyperandrogenism

The aim of research: to study the dependence of the level of hyperandrogenism and a number of characteristics of the porphyrinic fractions metabolism during physiological pregnancy and pregnancy complicated by fetoplacental insufficiency in women with hyperandrogenism. Research materials: 62 pregnant women 18-35 years old in the II-III trimesters of pregnancy. Methods of research: DHEAS and testosterone level determination, external cardiotocography, ultrasound, Doppler sonography, endogenous protoporphyrin and coproporphyrin of blood concentrations determination by spectral luminescent method; microviscosity of red blood cells membranes determination by pyren excimerization degree with fluorescent spectra measuring. Results of research: endogenous porphyrins of blood concentrations ratio in healthy expectant mothers and women with hyperandrogenism are quiet different. Inverse correlation dependence between dihydroepiandrosterone sulphate level and protoporphyrins to coproporphyrins concentrations ratio is obtained. Increase of red blood cells membranes microviscosity in pregnant women with hyperandrogenism is found. Presence of developed placental dysfunction in all women with hyperandrogenism by the end of II, beginning of III trimester of pregnancy is defined. Conclusion: relative decrease of protoporphyrin concentration to coproporphyrin one in pregnant women with hyperandrogenism is accompanied by the increase of microviscosity characteristics of red blood cells membranes, that deteriorates characteristics of fetoplacental blood flow and is confirmed by clinic laboratorial markers of placental insufficiency.