MicroRNA MIR-204-5P is a regulator of apoptosis in dacarbazine-resistant melanoma cells

Therapy for skin melanoma in its disseminated form is ineffective, among other things, due to the development of tumor cell resistance, mediated by various mechanisms. The acquisition of a stable cell phenotype is associated both with genetic and epigenetic changes mediated by the regulatory non-coding microRNA molecules. The aim hereof is to investigate the ability of microRNA miR-204-5p to influence changes in the cell cycle and apoptosis of melanoma cells resistant to the chemotherapeutic alkylating agent dacarbazine, used in standard chemotherapy for melanoma.