Myeloid suppressor cells in the pathogenesis of critical states

Critical states, regardless of the cause, are characterized by the formation of a systemic inflammatory response with multi-directional translations of pro- and anti-inflammatory mediators. Under the conditions of uncontrolled inflammation and the development of persistent organ failure, there exists a possibility of developing uncontrolled abnormal myelopoesis that might result in a release of myeloid suppressor cells. The purpose of the overview is to determine the role of myeloid suppressor cells in the development of immune suppression in critical states from the viewpoint of diagnostic significance, with the focus on both sterile and infectious systemic inflammation.