Urinary microbiome and its effect on colloidal stability in patients with urolithiasis

The aim of the paper is to study the correlation between urinary microbiome and Tamm-Horsfall protein (THP) structure in urolithiasis, and also to examine the possibility of their remodelling in relapsed patients. Materials and Methods. Two hundred seventy-three patients with urolithiasis underwent clinical and laboratory analysis. Among them there were 144 males (52.8 %) and 129 females (47.2 %), aged 21-76. Primary urolithiasis was observed in 142 patients (52.1 %); there were 131 relapsed patients (47.9 %), one-sided process was observed in 210 (76.3 %) and bilateral process in 63 subjects (23.7 %). As part of the study, 12 relapsed patients with urolithiasis were chosen for complex anti-relapse treatment, including 7 males (58.3 %) and 5 females (41.7 %), aged 37-52. In 3 patients (25 %) there was a spontaneous discharge of calculi after lithokinetic therapy, in 9 patients - after surgical treatment (8 patients after contact ureterolithotripsy, 1 patient after percutaneous nephron-lithotripsy)...