Микробиота и репродукция у сельскохозяйственных видов млекопитающих (обзор)

Микробиота и репродукция у сельскохозяйственных видов млекопитающих (обзор)

Автор: Попов Д.В.

Журнал: Сельскохозяйственная биология @agrobiology

Рубрика: Обзоры, проблемы

Статья в выпуске: 2 т.57, 2022 года.

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Использование специализированных пород животных сельскохозяйственных видов часто сопровождается снижением репродуктивного успеха. В молочном скотоводстве растет количество дней сервис-периода, процедур искусственного осеменения на одну стельность, частоты потерь стельности (С.В. Гуськова с соавт., 2014). Накопленные данные по получению эмбрионов методами in vivo и in vitro и их трансплантации свидетельствуют о значительных (30-60 %) потерях эмбрионов (P.J. Hansen, 2020). Причины низких показателей при применении репродуктивных технологий разнообразны и связаны как с биотическими, так и абиотическими факторами, при этом одним из ключевых при потерях эмбрионов может быть дисбаланс микробных сообществ в отделах репродуктивной системы как самок-доноров, так и самок-реципиентов. Изучение состава микробиоты различных отделов и систем многоклеточного организма в последнее время становится все более доминирующей темой в научной литературе. С появлением современных методов идентификации микробов, например метагеномного секвенирования, выявлено большое микробное разнообразие в разных анатомических отделах макроорганизмов. Накоплены данные о микробном составе и его динамике в органах репродуктивной системы, его связях с воспроизводством у млекопитающих, репродуктивным успехом, протеканием беременности, прогнозированием возможностей возникновения патологических процессов. В работе рассматриваются результаты исследований влияния микробиоты на успешность применения репродуктивных технологий, таких как экстракорпоральное оплодотворение, трансплантация эмбрионов, искусственное осеменение. Обсуждается (F. Marco-Jiménez с соавт., 2020) влияние симбиотических бактерий на фертильность и качество семени. Для млекопитающих это направление малоизучено, и крайне необходимо расширять изучение микробиоты репродуктивного тракта сельскохозяйственных животных. Результаты таких исследований дадут дополнительное понимание репродуктивных процессов и представление о причинах неудачных случаев и о положительных исходах воспроизводства. При этом практическое применение такой информации увеличит шансы успешно применять репродуктивные биотехнологии, снизит затраты, связанные с воспроизводством и терапевтическими вмешательствами при лечении патологий репродуктивной системы, а также откроет возможность для разработки и практического применения новых методов, в частности микробной терапии. Итак, можно сделать вывод, что микробиота органов репродуктивной системы млекопитающих оказывает влияние на физиологические процессы размножения (R. Koedooder с соавт., 2019), и при этом очевидно, что, имея возможность управлять микробными сообществами, человек может повысить шансы наступления репродуктивного успеха при воспроизводстве высокоспециализированных пород сельскохозяйственных животных (P.J. Hansen, 2020; R.W. Hyman с соавт., 2012; D.E. Moore с соавт., 2000).

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Эндометрий, микробиота, микробиом, репродуктивная система, сперма, матка, репродуктивные технологии

Короткий адрес: https://sciup.org/142235668

IDR: 142235668   |   DOI: 10.15389/agrobiology.2022.2.222rus

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