Microbiotic factor, health and stress-induced mental disorders

The article describes studies of multidimensional relationships between human microbiota factor, impact of stressors and associated with it mental health disorders, including stress-induced mental disorders. We present the analysis of theoretical and empirical studies of current state of the problem of intestinal and oral microbiota in the context of its impact on mental activity under normal and stressful influences, including procedures of experimentally induced stress. In the article we paid attention, firstly, to the analysis of multi-level relationships in the microbiota of the human gastrointestinal tract and, in particular, the oral microbiota as a representative correlate of the general characteristics of the intestinal microbiota. Secondly, we investigated the theoretical and described in the scientific literature empirically confirmed interrelations of changes in the microbiotic factor under chronic stress and acute experimental stress. Thirdly, we presented data on the correlation of microbiota, on the one hand, and the pathogenesis and symptoms of affective (anxious, depressive and anxious-depressive) disorders on the other hand. Fourth, we considered the foreign studies of microbiota in classical psychic (for example, autistic spectrum disorders) and neurodegenerative diseases (for example, Alzheimer's and Parkinson's diseases).