Multivariate analysis of structure and contribution per shares made by potential risk factors at malignant neoplasms in trachea, bronchial tubes and lung

He article gives the results of multivariate analysis of structure and contribution per shares made by potential risk factors at malignant neoplasms in trachea, bronchial tubes and lung. The authors used specialized databases comprising personified records on oncologic diseases in Taganrog, Rostov region, over 1986-2015 (30,684 registered cases of malignant neoplasms, including 3,480 cases of trachea cancer, bronchial tubes cancer, and lung cancer). When carrying out analytical research we applied both multivariate statistical techniques (factor analysis and hierarchical cluster correlation analysis) and conventional techniques of epidemiologic analysis including etiologic fraction calculation (EF), as well as an original technique of assessing actual (epidemiologic) risk. Average long-term morbidity with trachea, bronchial tubes and lung cancer over 2011-2015 amounts to 46.64 o/oooo. Over the last 15 years a stable decreasing trend has formed, annual average growth being -1.22 %. This localization holds the 3rd rank place in oncologic morbidity structure, its specific weight being 10.02 %. We determined etiological fraction (EF) for smoking as a priority risk factor causing trachea, bronchial tubes and lung cancer; this fraction amounts to 76.19 % for people aged 40 and older, and to 81.99 % for those aged 60 and older. Application of multivariate statistical techniques (factor analysis and cluster correlation analysis) in this research enabled us to make factor structure more simple; namely, to highlight, interpret, give a quantitative estimate of self-descriptiveness and rank four group (latent) potential risk factors causing lung cancer.