Molecular-genetic investigations in diagnosis and assessment of neoplastic progression of Barrett's esophagus (review)

The review systematizes data concerning markers of intestinal and gastric metaplasias (MUC1-MUC6, TFF1/TFF2, cytokeratins CK7, 8, 3,18,19,20, Her-2-Neu, cyclooxigenase-2, VEGF, transcription factor CDX2) in differentiated diagnosis of Barrett's esophagus (BE). Critical analysis of markers of BE neoplastic progression (Ki67, genes-tumor suppressors p53, APC, CDKN2 (pl6), some cyclins and cyclin-dependent kinase (CDK), pro-and antiapoptotic genes BCL2, BAX, BCL-XL, oncogenes c-k-ras, c-myb, c-myc, cell adhesion molecules, growth factors and chromosome aberrations) has been presented