Molecular-genetic factor analysis of inherited thrombophilia during gestosis

Molecular genetic factors of inherited thrombophilia of gestosis of different severity of 140 Russian women were studied. Control group was formed out of 150 recently delivered Russian mothers with physiological pregnancy. It was established that women who have inherited thrombophilia markers such as allelic variants C677T and A1298C of methylenetetrahydrofolate reductase gene (MTHFR), G20210A of prothrombin gene (F11), polymorphism of G1691A gene of the fifth factor of blood coagulability (FV), mutation of -675 4G/5G gene inhibitor plasminogen activator (PA1- 1) increase the risk of gestosis development of different severity to a great extant. So the molecular-genetic analysis of inherited thrombophilia should be taken into consideration in choosing the effective prophylaxis of gestosis.