Molecular genetic analysis of M235T angiotensinogen gene marker in the populations of different ethnic origin during gestosis

The purpose of this study is to analyze the association of M235T polymorphism of the angiotensinogen gene (AGT) with gestosis in the populations of different ethnic origin. 924 pregnant women from the three populations (Yakuts of city Yakutsk, n=329, Buryats of city UlanUde, n=305, Russians of city Tomsk, n=290) were examined, among them - 494 patients with gestosis. The control group included women with physiological pregnancy history. Data on the occurrence rate of the polymorphic variant M235T of AGT gene in populations of theYakuts, Buryats and Russians is analyzed. Association for the studied polymorphic variants with preeclampsia in the three populations is not established. A comparative analysis of the results with the world literature data on the prevalence of M235T polymorphism of AGT gene in world populations has been conducted.