Morphofunctional characterisitcs of periferal blood monocytes and their progenitors in progeny of female rats with autoimmune liver injury

Aim. To study how experimental autoimmune liver injury in mother influences morphofunctional features of monocyte development in the bone marrow of progeny. Materials and methods. The subjects of study were female Wistar rats with experimental liver injury and their progeny on days 30 and 60 of postnatal development divided into two groups: control and experimental. Chronic autoimmune liver injury was modeled using BCG vaccine via subcutaneous immunization with periodic intraperitoneal administration of liver antigen each three days. Results. The study showed that absolute cell count at all stages of development in the experimental group of animals decreased in comparison with the control group. Besides, the decrease was observed in PAS positive cell number, acid phosphatase activity and level of alpha-glycerophosphate dehydrogenase in monocyte series of the bone marrow and in peripheral blood monocytes of the groups of animals under observation. Conclusion. Mothers with experimental autoimmune hepatobiliary disorder give birth to progeny with disturbance expressed in functional immaturity of monocytes.