Morphological characteristics of pathological kidney changes in urolithiasis of guinea pig - Mus porcellus (clinical case)

The article describes a clinical case of urolithiasis in a guinea pig. The study material has been the kidneys of a guinea pig with complete obstruction of the urinary tract by urolithiasis. To assess the morphological structure of the kidneys, a classical histological technique has been used, a morphometric analysis of hematoxylin-eosin-stained material has been carried out using ImageJ 1.53 plugins, and statistical hypotheses (nonparametric criteria) have been tested in Programs Statistica 8.0 and Microsoft Excel 2016. The study has revealed complete obstruction of the urinary tract by urolithiasis, which has caused severe destructive changes in the epithelium of the proximal tubules of the kidneys and acute interstitial nephritis.