Morphological estimation of influence of urogenital infection on the structural organization of utero-placental junction in the first trimester of pregnancy

Objective: to evaluate morphological changes in the utero-placental region in the first trimester of pregnancy complicated with urogenital infection. Subjects: 90 women at gestational age 42-56 days, who planned abort for non-medical reasons are divided into 4 groups: 1st group - 16 pregnant women who had mycoplasmal colpitis and receiving specific treatment, 2nd group - 20 pregnant women who had nonspecific colpitis and received nonspecific therapy, third group of 31 pregnant women with asymptomatic mycoplasma infection, group 4 - 66 healthy pregnant women. Methods: clinical and history data studies; bacterioscopy exfoliative smears vaginal portion of the cervix; the identification of urogenital mycoplasma PCR, morphological study abortion material. Results: the morphological study abortion material show that the structure of the utero-placental region corresponded to gestation age. Specific volumes of stromal decidua basalis and decidua parietalis in the group with mycoplasma infection was half that of the control group and amounted to respectively 7.5, 8.0 and 17.3. On the other hand the content of decidua cells in the experimental group exceeded performance in the control group - 23.0 and the maximum value - 31.1 reached in the group of pregnant women with asymptomatic carriage of mycoplasmas (p=0,02) necrotic changes in the decidual tissue were observed equally often in all groups. Conclusion: all founded changes in the overall fit in the concept of compensatory-adaptive reactions inresponse tj the pathogenic effects of urogenital mycoplasmas. These changes are adaptive in nature and do not prevent the progression of pregnancy. Mycoplasmal colpitis antimicrobial therapy leads to normalization of the structural organization of the utero placental region.