Morphological and immunohistochemical mechanisms of evolution the chronic H. pylori-associated gastritis in stomach MALT-lymphoma

In dynamics 49 patients with I and II stages of stomach MALT-lymphoma aged from 60 till 74 years of subtypes A and B on classification of D. de Jong (1997) with lack of translocation - t (11,18) are examined. The expression of molecules of Ki-67, Bcl-2 and p53 in epithelial and lymphoid tissue of mucous membrane of a stomach before destination the eradication and chemotherapy and at achievement of morphological remission of disease was investigated. Existence of associative communication between progressing of atrophic gastritis, increase of expressiveness of an intestinal metaplasia, displasia of gastric epithelium, degree of a lymphoid hyperplasia of stomach mucous membrane, violation of expression the main regulatory molecules is confirmed (Bcl-2, Ki-67, p53). New mechanisms of progressing the chronic H. pylori-associated are installed gastritis with lymphoid hyperplasia at which final stage there is a formation of stomach MALT-lymphoma are installed. Achievement of clinical-endoscopic and morphological remission of MALT-lymphoma is followed by significant decrease in expression of the studied markers of cellular homeostasis (Ki-67, Bcl-2, p53).