Morphologic correlates of the multimodal electromagnetic exposures efficiency (as exemplified by the experiment tumor growth)
Автор: Barteneva Tatiana A., Shikhlyarova Alla I., Zhukova Galina V., Protasova Tatiana P., Bragina Marina I., Shirnina Elena A.
Журнал: Cardiometry @cardiometry
Рубрика: Original research
Статья в выпуске: 11, 2017 года.
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Aims The aim of the present paper is to study the morphofunctional changes in the tumor tissue and peripheral zone in experimental animals under the influence of extremely high-frequency electromagnetic radiation (EHF EMR). Combined effect of EHF EMR and ultra-low-frequency magnetic field (ULF MF) without the use of special anti-tumor agents is to be studied as well. Materials and methods The experiments have been performed on 56 outbred male rats with inoculated sarcoma 45. Low intensity EHF EMR and ULF MF exposures have been carried out only on animals’ heads. Histological and morphometric study of the sarcoma 45 tumor tissue and its peripheral area has been performed. Results In case of the combined electromagnetic exposure (in 65 % of cases) against the background of the sTable anti-stressor adaptation reactions an evident anti-tumor effect has been observed. Under effective combined electromagnetic action, lymphocyte infiltration of the tumor tissue and its peripheral zone was enhanced not only in comparison with the reference group, but also compared to the EHF EMR monoexposure. Conclusions Thus, significant enhancement of the tumor tissue infiltration by leukocyte cells under the combined effect of EHF EMR and ULF MF may indicate mobilization of the local immune mechanisms due to the activation of the neuroendocrine and immune system organs.
Electromagnetic exposure, antitumor effect, tumor infiltration, anti-stressor adaptation reaction
Короткий адрес: https://sciup.org/148308832
IDR: 148308832 | DOI: 10.12710/cardiometry.2017.11.4853
Список литературы Morphologic correlates of the multimodal electromagnetic exposures efficiency (as exemplified by the experiment tumor growth)
- Zhukova G.V. Use of activation therapy principles for increasing the antitumor efficiency in experiment: Dissertation. Rostov-on-Don, 2006. 50 p.
- Shikhlyarova AI. Role of biotropic parameters of electromagnetic fields in unspecific antitumor resistance increase: Dissertation. R-on-D, 2001. 50 p.
- Vadalà M, Morales-Medina JC, Vallelunga A, et al. Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology. Cancer Medicine. 1 November 2016;5(11):3128-39.
- Zakaria Z, Abdul Rahim R, Lee PY, et al. Review on interaction between electromagnetic field and biological tissues. Sensors and Transducers. 2012;143(8):60-70.
- Cap I, Barabas J. Low frequency electromagnetic fields:Friend or foe? Komunikacie. 2011;13(1):13-7.
- Lisi A, Foletti A, Ledda M, et al. Extremely low frequency 7 Hz 100 μt electromagnetic radiation promotes differentiation in the human epithelial cell line HaCaT. Electromagnetic Biology and Medicine. 1 December 2006;25(4):269-80.
- Börzsönyi L, Szabó F, Beckers JF, et al. Biometric investigation of human-and veterinary-biological effects of electromagnetic fields. Applied Ecology and Environmental Research. 2006;4(2):195-204
- Liboff AR. Toward an Electromagnetic Paradigm for Biology and Medicine. Journal of Alternative and Complementary Medicine. February 2004;10(1):41-7.
- Sheiko EA, Shikhlyarova AI, Kurkina TA. Low-energy red light radiation improves antitumor activity of cyclophosphamide. Bulletin of Experimental Biology and Medicine. December 2004;138(6):590-2.
- Sheiko YeA, Shikhlyarova AI, Kurkina TA. Experimental use of low-energy infra-red laser radiation to stimulate antitumor effect of cyclophosphane. Voprosy Onkologii. 2004;50(5):576-9.
- Sheiko YA, Shikhlyarova AI. Effect of low intensity laser radiation on neutrophil granulocyte functional potential in tumor-bearing animals. Voprosy Onkologii. 2003;49(1):76-80.
- Garkavi LKh, Kvakina EB, Mulatova AK, et al. Morphological and physiological characteristics of lymph nodes, thyroid gland, and testes of rats during stress-induced adaptation and activation. Bulletin of Experimental Biology and Medicine. November 1989;108(5):1669-73.
- Sheiko EA, Shikhlyarova AI, Maryanovskaya GI, et al. Experimental study of the effects of low intensity monochromatic photodiode radiation and antitumor efficiency of cyclophosphamide injected with autoblood. Bulletin of Experimental Biology and Medicine. May 2011;151(1):58-61.
- Garkavi LKh. Activation therapy. Anti-stressor reactions of activation and training and their use for recovery, prevention and treatment. Rostov-on-Don: Rostov University Publishing, 2006. 256 p.
- Garkavi LKh, Kvakina EB, Kuzmenko TS, Shikhlyarova AI. Anti-stressor reactions and activation therapy. Activation reaction as a way to health through self-organization processes. Ekaterinburg, 2003. 335 p.
- Goglova OO, Bogomolov AF. Ethics in work with experimental animals. Med. laws and eth. 2003;4:4-6.
- Garkavi LKh, Ukolova MA, Kvakina EB. Law of development of qualitatively different general adaptation reactions of the organism. Patent No.158, USSR. Moscow, 1975. p. 56-61. .
