Нагрузочные дозы статинов для предупреждения повреждения миокарда при плановых эндоваскулярных вмешательствах по поводу стабильной ишемической болезни сердца (обзор литературы)

Автор: Вершинина Елена Олеговна, Сальникова Елена Сергеевна, Репин Алексей Николаевич

Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk

Статья в выпуске: 4 т.29, 2014 года.

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Многими авторами было продемонстрировано, что после чрескожного коронарного вмешательства происходит увеличение уровня сердечных биомаркеров, что свидетельствует о гибели кардиомиоцитов и некрозе миокарда. В последнее время были опубликованы исследования, которые показали эффективность статинов для профилактики этих событий вследствие наличия у них плейотропных свойств. В обзоре представлены результаты основных исследований использования нагрузочных доз сильнодействующих статинов - аторвастатина (ARMIDA, ARMIDA-RECAPTURE, NAPLES II и др.) и розувастатина (ROMA, ROMA II и др.) - для предупреждения перипроцедурного повреждения миокарда у пациентов со стабильной ишемической болезнью сердца (ИБС). Приведенные данные поддерживают потребность в более частом назначении высоких доз статинов для всех пациентов, направленных на плановое чрескожное коронарное вмешательство (ЧКВ) по поводу стабильной стенокардии, в том числе не получавших ранее статины, а также необходимость перезагрузки статинами перед ЧКВ у пациентов, уже длительно их принимающих.

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Ибс, стабильная стенокардия, стентирование коронарных артерий, статины, перипроцедурное повреждение миокарда

Короткий адрес: https://sciup.org/14920301

IDR: 14920301

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