Our experience of examination of urological patients with high level of sex hormone-binding globulin

The role of hypogonadism is still underestimated in the pathogenesis of many urological diseases. One of the facets of hypogonadism is increasing of sex hormone-binding globulin (SHBG), the protein carrier of testosterone. In the article for the reference point was adopted norm of SHBG equal to the age of men. Over a two-year period were analyzed results of examinations 53 urological patients in whom SHBG exceeded for 10 units and more than the age of the patient. The most frequent diagnoses of patients were chronic prostatitis, erectile dysfunction, male infertility. Unfortunately, the testosterone deficiency continues to remain in the shadow of the diagnosis and treatment of inflammation of such androgen depending organ as prostate. The study highlighted the role of hypogonadism in the mechanism of prostatitis. The authors look at the usual paradigm of "insulin resistance - low SHBG" on the other hand, revealing half of patients with high level SHBG of insulin resistance. The increasing of SHBG by 10 units and more than the patient’s age is proposed to consider the new laboratory marker of hypogonadism independently of all other laboratory signs of testosterone deficiency.