Hereditary hemolytic anemia. Membranopathy (lecture) part 1

Hemolytic anemia (HA) is a pathology of erythrocytes and it is characterized by their accelerated destruction and the formation of erythrocyte breakdown products, the development of anemia and reactive erythropoiesis. In the 1st part of the lecture are presented the general concepts of hemolytic anemia, the main clinical and laboratory diagnostic criteria, the physiology and regulation of erythropoiesis, general aspects of the pathogenesis of HA and also are presented the clinical picture and a detailed classification. In this part of the article, hereditary hemolytic anemia caused by defects in the erythrocyte membrane is considered in detail. In the presented is diseases shown epidemiology, pathogenesis, clinical picture, differential diagnosis and treatment. The lecture is of particular interest to the audience of hematologists, transfusiologists, therapists, pediatricians, advanced training, as well as clinical residents and students of medical universities.