Hereditary thrombophilia as a risk for the development of ischemic stroke in children

The article deals with the causes of pediatric ischemic strokes. Hereditary thrombophilia was considered as one of the predisposing risk factors for ischemic stroke in childhood. We had included 37 children (19 girls and 18 boys) who underwent ischemic stroke and their parents in the study. The mean age of the first cerebral thrombosis was 10.5 ± 5.6 years. The stroke was connected with infections in 5 cases, with metabolic disorders - in 7, with congenital anomalies of cerebral vessels - in 3, with heart defects - in 2, and with epilepsy - in 1. Antibodies to phospholipids were detected in 16 / 43.2% children. 5 parents and 11 second-degree relatives had thromboses in the anamnesis. 4G / 5G plasminogen activator inhibitor-1 (PAI-1) was found in 25 children (14 heterozygotes, 11 homozygotes), methylenetetrahydrofolate reductase 677 C-T - in 21 (13 heterozygotes, 8 homozygotes), factor V 1691 G-A (factor V Leiden, heterozygote) was presented in 2 patients, 20210 G-A (factor II, heterozygote) - in 1. The percentage of inheritance of methylenetetrahydrofolate reductase 677 C-T was 52.3% from one parent and 90% - from two parents. The percentage 4G / 5G PAI-1 inheritance was 95.7%. The analysis of risk factors had shown that hereditary thrombophilia increased a risk for the development of ischemic stroke by 8 times.