Adverse left ventricular remodeling and the serum levels of matrix metalloproteinases, biomarkers of myocardium dysfunction and inflammation in patients with acute primary anterior stemi

The aim of this study was to assess the changes in serum levels of matrix metalloproteases (MMP-2, 3, 9), ST2, NTproBNP, IL1β, and hCRP and their impact on the adverse left ventricular remodeling (LVR) in patients with acute primary anterior STEMI. The study included 21 patients aged 60.5±7.4 years. All of them received urgent reperfusion therapy; one third of patients received the treatment during the first 3 h. Echocardiography with 2D speckle tracking imaging was performed at day 3 (T2), 7 (T3), and 14 (T4) after STEMI and after 6 months (T5) after AMI (Vivid E9, GE Healthcare). The concentrations of ММP-2, ММP-3, ММP-9, ST2, IL1β, hCRP, and NTproBNP were determined at the same time point and at a day of admission (T1) by the method of quantitative enzyme-linked immunosorbent assay. After that, patients were divided into 2 groups: group 1 comprised patients with the level of ST2 > 35 ng/mL; group 2 comprised patients with ST2