Neuropsychological status of patients with epilepsy and clinical manifestations of craniocerebral disproporation on the background of modified therapy

In the course of the study, 124 case records of patients with epileptic seizures (cryptogenic epilepsy) were analyzed. Diagnosis was established based on a typical clinical presentation, anamnesis, electroencephalogram (EEG) dynamics, and/or video EEG monitoring in the 10-hour format. Group I comprised 36 patients with normal liquor-cranial indexes ranging from 1.6 to 3.6 with an average value of 2.1±0.2; these patients received standard multicomponent therapy during the hospitalization and at the outpatient-polyclinic stage. Group II comprised 42 patients who had liquor-cranial indexes below the lower limit of normal ranging from 0.8 to 1.2 with an average value of 1.0±0.1; these patients also received therapy for primary diagnosis according to standard therapy scheme, which was identical to that in group I. Patients of group III (main group, n=46) had liquor-cranial indexes below physiological norm (from 0.8 to 1.2 with an average value of 0.9±0.1) and received modified therapy. Two-year follow up study showed that more severe cognitive deficit developed in patients with low cerebrovascular indexes receiving standard therapy compared to patients with low cerebrovascular indexes who received modified therapy. The absence of significant differences between patients of group I and III suggest that timely correction of increased intracranial pressure allowed to prevent significant aggravation of pathopsychological characteristics, loss of short-term and long-term memory, and overall cognitive function decline.