Некодирующие РНК в диагностике пневмонии

Автор: Михайлова С.В., Иванощук Д.Е., Шахтшнейдер Е.В., Степанов Г.А., Розанов А.С., Пельтек С.Е., Воевода М.И.

Журнал: Сибирский журнал клинической и экспериментальной медицины @cardiotomsk

Статья в выпуске: 3 т.34, 2019 года.

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Пневмония - тяжелое воспалительное заболевание, характеризующееся высокой смертностью во всем мире. Ранний диагноз внегоспитальной пневмонии и выявление вызвавшего ее инфекционного агента могут существенно снизить тяжесть ее течения и вероятность госпитализации пациента. Используемые на данный момент диагностические и прогностические методы не являются достаточно надежными, поэтому ряд специфических некодирующих РНК, циркулирующих в крови в составе внеклеточных везикул, рассматривают в последние годы как потенциальный биомаркер для дифференциации вирусных и бактериальных пневмоний, а также для предсказания осложнений и тяжести течения заболевания. В обзоре рассмотрены микроРНК, длинные некодирующие РНК и ксено-микроРНК, которые были предложены в качестве прогностических и диагностических маркеров, а также потенциальных таргетных препаратов при пневмонии.

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Пневмония, микрорнк, ксено-микрорнк, длинные некодирующие рнк, внеклеточные везикулы, биомаркер

Короткий адрес: https://sciup.org/149126154

IDR: 149126154 | DOI: 10.29001/2073-8552-2019-34-4-72-82

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