Некоторые особенности коррекции дисфункции жировой ткани

Некоторые особенности коррекции дисфункции жировой ткани

Автор: Филинюк П.Ю., Шишкин А.Н., Пчелин И.Ю., Худякова Н.В., Воловникова В.А., Кулибаба Т.Г.

Журнал: Juvenis scientia @jscientia

Рубрика: Обзорные статьи

Статья в выпуске: 6 т.9, 2023 года.

Бесплатный доступ

Стремительное распространение ожирения и ассоциированных с ним сердечно-сосудистых заболеваний вызывает серьёзную обеспокоенность в научно-медицинской сфере. Несмотря на многообразные подходы к решению данных проблем, до сих пор отсутствуют видимые успехи в борьбе с ожирением на популяционном уровне, а кардиоваскулярная патология всё ещё остаётся одной из главных причин смертности и инвалидизации в мире. Это ведёт к закономерным попыткам найти новые терапевтические пути. Одним из таких направлений может стать таргетная фармакологическая терапия дисфункции жировой ткани. Данная статья посвящена обзору эффектов таких адипоцитокинов, как адипонектин и лептин, одних из самых хорошо изученных маркеров нарушения функционирования жировой ткани, а также некоторых современных подходов к медикаментозной коррекции их влияний на сердечно-сосудистую систему. Проведённый анализ данных показывает, что гипоадипонектинемия и гиперлептинемия в сочетании с лептинорезистентностью ассоциируются с кардиоваскулярными заболеваниями и неблагоприятным прогнозом, а коррекция патологически изменённых уровней вышеупомянутых адипоцитокинов с достижением их оптимального соотношения может являться значимой терапевтической целью.

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Сердечно-сосудистые заболевания, ожирение, адипоцитокины, адипонектин, лептин

Короткий адрес: https://sciup.org/14129343

IDR: 14129343   |   DOI: 10.32415/jscientia_2023_9_6_6-17

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