Nonspecific resistance of newborn calves after application of sodium nucleinate to dоwn-calving cows

The aim of the study was to study the use of the immunomodulator Sodium nucleinate for the development of nonspecific resistance in newborn calves. The work was carried out on the basis of the APC «Nizhegorodets» of the Nizhny Novgorod region. In the course of the experiment, a biochemical and immunological analysis of the blood of newborn calves was carried out on the second and tenth days after birth. As a result, there was an increase in gamma globulins by 53,5%. This effect may be due to both a higher content of immunoglobulins in colostrum and an increase in their assimilation in the intestines of newborns. Immunoglobulins can perform the function of opsonization, therefore, apparently, their higher content caused an increase in the phagocytic activity of neutrophils and the phagocytic index, respectively, by 15.4 and 36 %. The level of bactericidal activity and lysozyme activity of blood serum were also higher in the experimental calves. On the 10th day, the positive effect persisted.