Unstable angina in intact coronary arteries: clinical aspects and prognosis

Introduction. The phenomenon of «unstable angina» in patients with nearly unchanged coronary arteries was found out in the 1960s. The recent data show that degree of incidence of intact coronary arteries varies from 10 to 30 %. Objective. The work study is to examine facts associated with «unstable angina» in intact coronary arteries. Materials and Methods. The study enrolled 70 patients with the diagnosis «unstable angina» in intact coronary arteries. The coronary angiography was obtained with «Simens Axion Artis» (Germany). The standart laboratory tests were hold on «Olympus AU400» (Japan). Acusson S2000 (Japan) was used to analyze echocardiograms. The results of Holter ECG monitoring were analyzed with «Kardiotekh-nika - 04-8(M)» («Inkart», Russia). Statistical data processing was conducted using software package Statistica 10.0 (StatSoft). Results. Nearly 30 % of women aged up to 70 years old with unstable angina have intact coronary arteries. The most common background cardiac pathology in such patients is arterial hypertension. The risk of the myocardial infarction in this group increases if patients also have diabetes mellitus type 2. Changes in the lipid spectrum with intact coronary arteries evidence the pathology of thyroid glands. According to echocardiography patients with intact coronary arteries usually have preserved ejection fraction. This category of patients demonstrates near-normal circadian index level. Conclusion. Probability of unstable angina in patients with intact coronary arteries is rather high if women aged up to 70 years old have both arterial hypertension and pathology of thyroid glands (hypothyroidism, carbohydrate metabolism disorders). It is recommended to include the detection of thyroid harmone level in diagnostic search while diagnosing intact coronary arteries.