New approaches to prophylaxis and therapy of ischemic and reperfusion damages of the heart at acute myocardial infarction

Analysis of literature data testifies that protective effect of adenosine at acute myocardial infarction (AMI) apparently is not depend upon a decrease in the infarct size but is a consequence of a decrease of a rate of noreflow phenomenon appearance. Protective effect of nicorandil observed in patients with AMI apparently is linked to an improvement of coronary perfusion in the periinfarction border zone. Opioids and cannabinoids mimic pre and postconditioning phenomenon. Thus, these compounds can be used in the complex therapy of AMI after clinical trial. Phytoadaptogenes can became a prototype for a creation of drugs increased cardiac tolerance to ischemic and reperfusion damages.